| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-164 | |
| Phytochemical name or plant extracts | Paclitaxel | |
| PMID | 7669713 | |
| Literature evidence | Paclitaxel was administered by 3-hour intravenous infusion every three weeks in all patients, and if possible, all were evaluated neurologically before paclitaxel, after every other cycle and after discontinuation of therapy. | |
| IUPAC name | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Taxus brevifolia | |
| Geographical availability | Alaska, Alberta, British Columbia, California, Idaho, Montana, Oregon, Washington | |
| Plant parts | Bark | |
| Other cancers | Ovarian cancer, Breast cancer, Lung cancer, Head and neck cancer | |
| Target gene or protein | EF1a ,FOXO3a, Bcl-2 | |
| Gene or Protein evidence | Paclitaxel increased the phosphorylation of AMPK and also downregulated the expression of EF1α in MCF7 cells. Paclitaxel suppresses the viability of breast tumor MCF7 cells through the regulation of EF1α and FOXO3a by AMPK signaling. | |
| Target pathways | AMPK/EF1α/FOXO3a signaling pathway | |
| IC50 | 33.7 ± 4.2 nM against MCF-7 | |
| Potency | Paclitaxel is a plant taxane mitotic inhibitor approved for primary or salvage treatment of ovarian and breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Paclitaxel is more likely to be associated with peripheral neuropathy and myalgias/arthralgias than docetaxel. | |
| PubChem ID | 36314 | |
| Additional PMIDs | 33357719 7908664 7551941 10344150 26179168 7619331 15907983 26397839 21796250 24152585 25981924 26124351 9891802 15846465 7610396 17152485 17152485 18985033 18668363 23844611 25442283 27056899 28314310 30849160 31708973 33823894 34280009 7910054 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:249736-2 | |
| Safety | NA |