| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1328 | |
| Phytochemical name or plant extracts | PH-1 (4-methyl-5-oxo-tetrahydrofuran-3-yl acetate) | |
| PMID | 34560864 | |
| Literature evidence | This study was aimed to isolate potential anticancer compounds from its most potent fractions and evaluate their anticancer potentials. | |
| IUPAC name | (4-methyl-5-oxooxolan-3-yl) acetate | |
| Phytochemicals’ class or type of plant extracts | Esters and cyclic ether | |
| Source of phytochemicals or plant Extracts | Polygonum hydropiper | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Amur, Andaman Is., Assam, Austria, Azores, Baltic States, Bangladesh, Belarus, Belgium, Bulgaria, Buryatiya, Central European Russia, China South-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East European Russia, East Himalaya, Finland, France, Germany, Great Britain, Greece, Hainan, Hungary, India, Inner Mongolia, Iran, Ireland, Irkutsk, Italy, Japan, Jawa, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Kuril Is., Madeira, Malaya, Manchuria, Mongolia, Morocco, Myanmar, Nansei-shoto, Nepal, Netherlands, New South Wales, Nicobar Is., North Caucasus, North European Russia, Northwest European Russia, Norway, Ogasawara-shoto, Pakistan, Philippines, Poland, Portugal, Primorye, Qinghai, Queensland, Romania, Sakhalin, Sardegna, Sicilia, South Australia, South European Russia, Spain, Sri Lanka, Sumatera, Sweden, Switzerland, Tadzhikistan, Taiwan, Tasmania, Thailand, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Tuva, Ukraine, Uzbekistan, Victoria, Vietnam, West Himalaya, West Siberia, Western Australia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 340 µgm/L | |
| Potency | LD50 of 340 µgL-1 (Anti-tumor assay) | |
| Cell line/ mice model | MCF-7, HeLA, NIH/3T3 | |
| Additional information | The compound cause considerable cytotoxicity against cancer cells. The anti-angiogenic and anti-tumor results suggests additional tumor suppressive properties. | |
| PubChem ID | 15743484 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77069479-1 | |
| Safety | In anti-tumor assay, PH-1 and PH-2 exhibited 81.15 and 76.09% inhibitions with LD50 of 340 and 550 µgL-1 respectively. |