| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-189 | |
| Phytochemical name or plant extracts | P-coumaric acid | |
| PMID | 28939230 | |
| Literature evidence | The optimal concentration of DPPH was determined, and six potential antioxidants including 4-hydroxyphenylacetic acid, p-coumaric acid, ferulic acid, quercitrin, astragalin, and quercetin, and three non-antioxidants including benzoic acid, coptisine, and berberine, were successfully screened out and validated by conventional DPPH radical scavenging activity assay. | |
| IUPAC name | (E)-3-(4-hydroxyphenyl)prop-2-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Polyphenolic compound | |
| Source of phytochemicals or plant Extracts | Carrichtera annua | |
| Geographical availability | Algeria, Baleares, Canary Is., Cyprus, Egypt, Greece, Iran, Iraq, Kriti, Kuwait, Lebanon-Syria, Libya, Morocco, Palestine, Portugal, Sardegna, Saudi Arabia, Sicilia, Sinai, Tunisia, Western Sahara | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer, Liver cancer | |
| Target gene or protein | p53, p21, CDK4 | |
| Gene or Protein evidence | Exposure to p-coumaric acid increased p53 and p21 expression but decreased CDK4 levels in both cell types, which could result in the observed G0/G1 arrest. | |
| Target pathways | NA | |
| IC50 | 474 µM against T47D | |
| Potency | NA | |
| Cell line/ mice model | SW 620, Hep G2, A549, T47D, HeLa, MCF-7 | |
| Additional information | NA | |
| PubChem ID | 637542 | |
| Additional PMIDs | 34064100 24858101 32847047 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:280826-1 | |
| Safety | NA |