| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1508 | |
| Phytochemical name or plant extracts | Oxyresveratrol | |
| PMID | 34305605 | |
| Literature evidence | Apoptosis was activated through mitochondria-lost membrane potential, caspase-3 expression and chromatin condensation without DNA damage. | |
| IUPAC name | 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Artocarpus lakoocha Wall ex | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Cambodia, China South-Central, East Himalaya, India, Laos, Myanmar, Nepal, Thailand, Vietnam, West Himalaya | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Prostate cancer | |
| Target gene or protein | Rad51 | |
| Gene or Protein evidence | Rad51 gene (DNA repair pathway) was significantly down-regulated | |
| Target pathways | OXY has been reported to exhibit autophagy independently from apoptosis in neuroblastoma cells. The molecular targets were mostly via inhibition of PI3K/AKT/mTOR/pS6 signalling and activation of p38 MAPK pathway | |
| IC50 | 30.64 ± 4.79 µM against MCF-7 | |
| Potency | These results indicate that OXY moderates key genes and pathways in MCF-7 cells and that it could be developed as a chemotherapy or chemo-sensitizing agent. | |
| Cell line/ mice model | MCF-7, HepG2, PC–3, RAW 264.7 and A–549 | |
| Additional information | OXY has been reported to exhibit autophagy independently from apoptosis in neuroblastoma cells. | |
| PubChem ID | 5281717 | |
| Additional PMIDs | 34305605 28484893 30822142 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:850405-1 | |
| Safety | NA |