| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-381 | |
| Phytochemical name or plant extracts | Ovatodiolide | |
| PMID | 27136586 | |
| Literature evidence | Overexpression of Hsp27 or knockdown of SMURF2 in AS-B145 cells diminished the therapeutic effect of ovatodiolide in the suppression of mammosphere formation. | |
| IUPAC name | (1R,3E,5S,9R,12E)-3,12-dimethyl-8-methylidene-6,18-dioxatricyclo[14.2.1.05,9]nonadeca-3,12,16(19)-triene-7,17-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Anisomeles indica | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, Christmas I., East Himalaya, India, Jawa, Laccadive Is., Laos, Lesser Sunda Is., Malaya, Maldives, Maluku, Myanmar, Nansei-shoto, Nepal, New Guinea, Nicobar Is., Pakistan, Philippines, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Tibet, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Oct4, Nanog, Hsp27, SMURF2 | |
| Gene or Protein evidence | Ova dose-dependently downregulated the expression of stemness genes, octamer-binding transcription factor 4 (Oct4) and Nanog, as well as heat shock protein 27 (Hsp27), but upregulated SMAD ubiquitin regulatory factor 2 (SMURF2) in mammosphere cells derived from AS-B145 or BT-474. | |
| Target pathways | NA | |
| IC50 | 4.80 ± 1.06 μM against BT-474 | |
| Potency | In summary, our data reveal that Ova displays an anti-CSC activity through SMURF2-mediated downregulation of Hsp27. Ova could be further developed as an anti-CSC agent in the treatment of breast cancer. | |
| Cell line/ mice model | AS-B145, BT-474 | |
| Additional information | Overexpression of Hsp27 or knockdown of SMURF2 in AS-B145 cells diminished the therapeutic effect of ovatodiolide in the suppression of mammosphere formation. | |
| PubChem ID | 6451060 | |
| Additional PMIDs | 22033475 27136586 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:444831-1 | |
| Safety | NA |