| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1231 | |
| Phytochemical name or plant extracts | Oroxylum indicum (PHO) extract | |
| PMID | 22938449 | |
| Literature evidence | Cytotoxicity, apoptosis induction and anti-metastatic potential of Oroxylum indicum in human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Petroleum ether extract | |
| Source of phytochemicals or plant Extracts | Oroxylum indicum | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, India, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, Nepal, Philippines, Sri Lanka, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya | |
| Plant parts | Leaves and fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9, ICAMP1, Caspase 3 | |
| Gene or Protein evidence | Further, the O. indicum leaf extract caused a reduction in MCF-7 cell viability, induction of MCF-7 cell apoptosis and ROS formation, and an increase in caspase 3 activity. Also, the two extracts inhibited MCF-7 cell migration and reduced both MMP 9 and ICAMP1 gene expression and MMP9 protein expression. | |
| Target pathways | Additionally, O. indicum extracts greatly reduced expression of the cell cycle regulatory protein Rac1 in the mevalonate pathway. | |
| IC50 | Leaves extract - 57.02 ± 2.85 µg/mL against MCF-7 Fruits extract - 131.3 ± 19.2 µg/mL against MCF-7 | |
| Potency | Conclusively, the non-polar extract of O. indicum consequently possess effectual cytotoxicity and distinctive apoptosis-inducing abilities, along with evident antimetastatic potentials and thus could be considered as a hitherto unreported source of bioactive phytochemicals for the development of efficacious and possibly specific anticancer agents against ER-negative breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, WRL-68 | |
| Additional information | In summary, O. indicum leaf and fruit extracts reduce breast cancer cell growth, cell viability and cell migration. O. indicum constituents could, therefore, be useful for augmenting the activity of chemotherapeutic drugs employed to treat breast cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | 14719119 29890668 32373390 22938449 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:110175-1 | |
| Safety | NA |