| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-674 | |
| Phytochemical name or plant extracts | Orobanche crenata extract | |
| PMID | 32367771 | |
| Literature evidence | We aimed to assess the antitumor activity of Orobanche crenata methanolic extract and evaluate its cytotoxic effect on different cancer cell lines to develop an effective natural anticancer drug. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanoic extract | |
| Source of phytochemicals or plant Extracts | Orobanche crenata | |
| Geographical availability | Algeria, Azores, Baleares, Bulgaria, Canary Is., Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Iran, Iraq, Italy, Kriti, Krym, Libya, Madeira, Morocco, North Caucasus, Palestine, Portugal, Sardegna, Sicilia, Sinai, Spain, Tunisia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colon cancer, Prostate cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 89.6 µg/mL against MCF-7 | |
| Potency | In conclusion, our findings suggested that the O. crenata extract possesses potent antioxidant, cytotoxic activity, and anticancer properties which are possibly due to the principal bioactive phytochemical composites existing in this plant. These results can be used to develop new drugs for cancer treatment. | |
| Cell line/ mice model | HepG2, PC3, MCF-7, and HCT-116 | |
| Additional information | In addition, treatment of HCT-116 with various concentrations of the extract caused the release of lactate dehydrogenase and induction of caspase-3 activity in a dose-dependent way. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:662275-1 | |
| Safety | NA |