| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-395 | |
| Phytochemical name or plant extracts | Origanum acutidens extract | |
| PMID | 23613392 | |
| Literature evidence | PURPOSE: There has been a long-standing interest in the identification of medicinal plants and derived natural products for developing anticancer agents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous Extract | |
| Source of phytochemicals or plant Extracts | Origanum acutidens | |
| Geographical availability | Iraq, Turkey | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 7 | |
| Gene or Protein evidence | Annexin-positive cells level in OA-treated cell lines were significantly higher compared with untreated control cells (p=0.002). The expressions of caspase-7 protein and TUNEL-positive cells were much higher for the rats treated by OA, compared with the untreated control group (p<0.05). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These results indicate that OA has antitumor activity against breast cancer cell lines. | |
| Cell line/ mice model | MCF-7, MDA-MB-468, MDA-MB-231 | |
| Additional information | In vivo studies showed that the mean tumor volume inhibition ratio in OA-treated group was 41 % compared with the untreated rats (p<0.05). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:453185-1 | |
| Safety | NA |