| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-242 | |
| Phytochemical name or plant extracts | Orientin | |
| PMID | 27630565 | |
| Literature evidence | Our data revealed that flax C-glucosides as well as pure compounds are cytotoxic toward MCF-7 cells and inhibit their proliferation. | |
| IUPAC name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Oryza sativa | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP9, IL-8 | |
| Gene or Protein evidence | Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCα and ERK activation, as well as the nuclear translocation of AP-1 and STAT3. | |
| Target pathways | PKCα/ ERK/AP-1/STAT3-mediated signaling pathways | |
| IC50 | NA | |
| Potency | The inhibition was stronger after 48 h of treatment and showed that vitexin reduced proliferation by up to 40% of the control value, while isoorientin inhibited proliferation by up to 50% , and orientin by up to 55% | |
| Cell line/ mice model | MCF-7 | |
| Additional information | These results clearly demonstrated that flax straw metabolites effectively induced growth inhibition and apoptosis in human breast adenocarcinoma cells. | |
| PubChem ID | NA | |
| Additional PMIDs | 35215267 30466990 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316812-2 | |
| Safety | NA |