| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-955 | |
| Phytochemical name or plant extracts | Oridonin | |
| PMID | 23746196 | |
| Literature evidence | These new analogues obtained by rationally modifying the natural product have been demonstrated not only to significantly induce the apoptosis and suppress growth of triple-negative MDA-MB-231 breast cancer both in vitro and in vivo but also effective against drug-resistant ER-positive MCF-7 clones. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Isodon rubescens | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Caspase 3, PARP, AKT | |
| Gene or Protein evidence | The results showed that oridonin exhibited a significant effect in inducing apoptosis of MDA-MB-231 cells, enhancing intracellular ROS level, down-regulating expression of Bcl-2 protein, and promoting cleavage of caspase-3 and its substrate PARP. Oridonin binds to AKT1 and potentially functions as an ATP-competitive AKT inhibitor. | |
| Target pathways | Ras/Raf/ERK signal pathway Integrin β1/FAK pathway HIF-1α/VEGF signaling pathway PI3K/AKT signaling | |
| IC50 | NA | |
| Potency | Moreover, oridonin also inhibited tumor invasion and metastasis in vitro possibly via decreasing the expression of MMPs and regulating the Integrin β1/FAK pathway in MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231 , MCF-7, A375-S2 | |
| Additional information | CONCLUSION: Our results suggest that the inhibitive effect of oridonin is likely to be driven by the inhibition of Notch signaling pathway and the resulting increased apoptosis. | |
| PubChem ID | 5321010 | |
| Additional PMIDs | 29844859 17251686 25491140 29580806 15008459 23336515 28579904 30008931 28165738 32853925 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:915158-1 | |
| Safety | NA |