| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-951 | |
| Phytochemical name or plant extracts | Oplopantriol A | |
| PMID | 23746754 | |
| Literature evidence | Results from this study supplied valuable information for future semi-synthesis of polyyne derivatives to develop novel cancer chemopreventive agents. | |
| IUPAC name | (9E,11S,16S)-octadeca-9,17-dien-12,14-diyne-1,11,16-triol | |
| Phytochemicals’ class or type of plant extracts | Polyynes | |
| Source of phytochemicals or plant Extracts | Oplopanax horridus | |
| Geographical availability | Alaska, Alberta, British Columbia, Idaho, Michigan, Montana, Ontario, Oregon, Washington, Yukon | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Colon cancer, colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | At 10 μM, compound 5 (oplopantriol A) inhibited cell growth by 76.4% (p < 0.01), while compound 1 (falcarindiol) inhibited cell growth by 98.1% (p < 0.01). | |
| Cell line/ mice model | MCF-7, HCT-116, SW-480 | |
| Additional information | Among the 13 compounds, strong antiproliferative effects were observed from falcarindiol and a novel compound oplopantriol A. | |
| PubChem ID | 86311066 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:91131-1 | |
| Safety | NA |