| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1148 | |
| Phytochemical name or plant extracts | Ophiopogonin D | |
| PMID | 32818624 | |
| Literature evidence | Meanwhile, Ophiopogonin D significantly inhibited TGF-β1-induced metastatic behavior of MDA-MB-231 cells, including EMT, anoikis resistance as well as migration and invasion, via suppressing MMP-9 activity. | |
| IUPAC name | (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-hydroxy-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,14R,16R)-16-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14-yl]oxy-6-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Steroidal glycoside | |
| Source of phytochemicals or plant Extracts | Ophiopogon japonicus | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Korea, Philippines, Taiwan, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | TGF-β1, ITGB1, MMP9, FAK, Src, AKT | |
| Gene or Protein evidence | Ophiopogonin D inhibited TGF-β1-induced metastasis via suppressing MMP-9 activity. ITGB1 overexpression partly recovered Ophiopogonin D's inhibitory effect on metastatic behavior via activating MMP-9. Mechanically, Ophiopogonin D achieved its effect through efficiently abolishing ITGB1 expression, thus reducing the phosphorylation of FAK, Src and AKT, as well as upregulating nuclear β-catenin. | |
| Target pathways | Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis | |
| IC50 | 92.91 μM against Hs 578Bst | |
| Potency | Ophiopogonin D inhibited TGF-β1-induced metastatic behavior of MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231, Hs 578Bst | |
| Additional information | Ophiopogonin D (less than 100μmol·L~(-1)) can selectively induce the expressions of CYP2J2 and CYP4F3,regulate the metabolic pathway of fatty acid signaling molecules,and thus protecting the cardiovascular system. | |
| PubChem ID | 46173859 | |
| Additional PMIDs | 34402291 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:429781-1 | |
| Safety | NA |