| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1765 | |
| Phytochemical name or plant extracts | Ophiobolin O | |
| PMID | 22130129 | |
| Literature evidence | Ophiobolin O is a natural compound that has been isolated from Aspergillus ustus 094102. | |
| IUPAC name | (1S,3R,6R,7S,9E,11S,13S,15R,16S)-11,13-dimethoxy-3,15-dimethyl-6-[(2S,3Z)-6-methylhepta-3,5-dien-2-yl]-12-oxatetracyclo[8.5.1.03,7.013,16]hexadec-9-en-15-ol | |
| Phytochemicals’ class or type of plant extracts | Sesterterpenoid | |
| Source of phytochemicals or plant Extracts | Aspergillus ustus 094102 | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | JNK, p38 MAPK, ERK, Bcl-2 phosphorylation (Ser70) | |
| Gene or Protein evidence | Ophiobolin O also caused the activation of JNK (c-Jun NH(2)-terminal kinase), p38 MAPK (mitogen activated protein kinase) and ERK (extracellular signal-regulated kinase) as well as the degradation of Bcl-2 phosphorylation (Ser70). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, ophiobolin O may be considered as a novel therapeutic agent in breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The results of present study show that ophiobolin O induced cycle G(0)/G(1) phase arrest in MCF-7 cells using a cell cycle analysis. In addition, we demonstrated that ophiobolin O reduced the viability of human breast cancer MCF-7 cells in a time- and dose-dependent manner and efficiently induced apoptosis in MCF-7 cells using the Annexin V/PI binding assay. | |
| PubChem ID | 56835176 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |