| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1584 | |
| Phytochemical name or plant extracts | Oleic acid | |
| PMID | 18069902 | |
| Literature evidence | Oleic acid, a monounsaturated fatty acid, has shown activity in cancer prevention, while squalene has also been identified as having anticancer effects. | |
| IUPAC name | (Z)-octadec-9-enoic acid | |
| Phytochemicals’ class or type of plant extracts | Monounsaturated fatty acid | |
| Source of phytochemicals or plant Extracts | Olea europaea | |
| Geographical availability | Afghanistan, Albania, Algeria, Angola, Baleares, Botswana, Burundi, Canary Is., Cape Provinces, China South-Central, Cyprus, Djibouti, East Aegean Is., Eritrea, Ethiopia, Free State, Greece, Iran, Italy, Kenya, Kriti, KwaZulu-Natal, Lesotho, Libya, Madeira, Malawi, Mauritius, Morocco, Mozambique, Namibia, Nepal, Niger, Northern Provinces, Oman, Pakistan, Palestine, Portugal, Rwanda, Réunion, Sardegna, Saudi Arabia, Sicilia, Somalia, Spain, Sudan, Swaziland, Tanzania, Tunisia, Turkey, Turkey-in-Europe, Uganda, West Himalaya, Yemen, Yugoslavia, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | Her-2/neu (erbB-2), BCRP, FAS | |
| Gene or Protein evidence | Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Gene expression of BCRP was increased after exposure to oleic acid for 6 h, but the amount of BCRP protein was not increased. Indeed, OA exposure significantly reduced FAS activity and expression by 55% in FAS-overexpressing SK-Br3 cells. | |
| Target pathways | Oleic acid promotes migration on MDA-MB-231 breast cancer cells through an arachidonic acid-dependent pathway. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231, SKBR-3, caco-2, A549 | |
| Additional information | The results showed that oleic acid (25.39%) and palmitic acid (21.798%) are the main anticancer compounds present in AME. Therefore, oleic acid and OEA may prevent cancer formation through STAT phosphorylation with IFN-γ. These findings provide novel insights into the anti-cancer effects of oleic acid-rich oil, such as olive oil. In A549 cells, oleic acid and OEA decreased IFN-?-induced expression of PD-L1, Bax, Bcl-2, and caspase 3. Oleic acid and OEA decreased IFN-?-induced phosphorylation of STAT. These results indicate that oleic acid and OEA inhibit PD-1 expression, and induce apoptosis via STAT phosphorylation. Therefore, oleic acid and OEA may prevent cancer formation through STAT phosphorylation with IFN-?. These findings provide novel insights into the anti-cancer effects of oleic acid-rich oil, such as olive oil. | |
| PubChem ID | 445639 | |
| Additional PMIDs | 30259402 19931412 34400394 7579484 9665107 22819932 26071310 33957086 32462976 21781051 28242901 30021342 31275405 9466659 34903977 33812607 26246833 1943498 26990649 11895875 14767544 15642702 17134970 17704032 18584483 18208790 25222131 28577869 1998946 8072032 9193329 11239764 33209199 19266226 30601995 32727783 33802121 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:610675-1 | |
| Safety | NA |