| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1335 | |
| Phytochemical name or plant extracts | Oleanolic acid | |
| PMID | 23479388 | |
| Literature evidence | Most of these compounds showed significant cytotoxic activities against four human cancer cell lines (A549, HCT116, MDA-MB-231, and CCRF-CEM), and the structure-activity relationships are also discussed. | |
| IUPAC name | (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Gleditsia sinensis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Manchuria | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer, Colon cancer, Leukemia, Prostate cancer, Glioma,Liver cancer, Cervical cancer | |
| Target gene or protein | ABCB1, CDK2, CDK4, CD34, Cyclin E, Cyclin D1, p-JNK, p-ERK, p21, p27, p53, cyt-c, Bax, PARP-1, VEGF-B, AMPK, VEGFR-2, Caspase 3, mTOR/FRAP1, RAPTOR, RICTOR, VEGF | |
| Gene or Protein evidence | Induces G1 cell arrest via activation of p-JNK, p-ERK, p21, and p27, and the decrease in p-AKT, cyclin D1, CDK4, cyclin E, and CDK2 (MCF-7), induces G12 cell arrest via activation of p-AKT, p-JNK, p21 and p27, and the decrease in p-ERK, cyclin B1 and CDK2 expression. Besides, they displayed reduction in CD34 expression, confirming their antiangiogenic effect. Decrease of ABCB1 protein expression and increase of G(1) phase arrest induced by oleanolic acid in human multidrug-resistant cancer cells. This enhanced apoptosis was due to increases in p53, cytochrome c, Bax, PARP-1 and caspase-3 expression in DU145, MCF-7 and U87 cell lines. OA was found to activate AMP-activated protein kinase (AMPK), the master regulator of metabolism, in prostate cancer cell line PC-3 and breast cancer cell line MCF-7. Decreases both serum vascular endothelial growth factor B (VEGF-B) levels and vascular endothelial growth factor receptor 2 (VEGFR-2) expression Causes specific inhibition of LR-mediated survival signaling, namely mTORC1 and mTORC2 activities, by decreasing the levels of the mTOR/FRAP1, RAPTOR and RICTOR. This work provides evidence of VEGF promoter i-motif as an anticancer target and will facilitate future efforts for the discovery of oleanolic acid-based selective ligands of VEGF promoter i-motif. | |
| Target pathways | Induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway(PC-3 and MCF-7). Oleanolic acid induces p53-dependent apoptosis via the ERK/JNK/AKT pathway in cancer cell lines in prostatic cancer xenografts in mice. | |
| IC50 | > 100 µM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | A549, MDA-MB-231, PC-3, MCF-7, DU145, U87, HT-29, HDFn, HepG-2, Bel-7402, HeLa, MDA-MB-468, HCT-116, T-47D, HL-60/HAR, K562, A354-S2 | |
| Additional information | NA | |
| PubChem ID | 10494 | |
| Additional PMIDs | 25075040 24856665 28231262 34055052 34685891 33568035 34421584 25046839 26225949 29899865 16029005 27453990 28278660 24459770 22855944 22623883 29397094 28839362 30870993 20027631 21954959 34440504 25486328 24548556 30108878 29568181 29468899 22976320 26559244 19132288 22796399 34058937 33567767 26902601 28322779 34365127 34390971 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:295229-1 | |
| Safety | NA |