| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-669 | |
| Phytochemical name or plant extracts | Olea europaea extract | |
| PMID | 27585256 | |
| Literature evidence | Aromatase inhibitors (AIs) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (ER+) breast cancers. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Olea europaea | |
| Geographical availability | Afghanistan, Albania, Algeria, Angola, Baleares, Botswana, Burundi, Canary Is., Cape Provinces, China South-Central, Cyprus, Djibouti, East Aegean Is., Eritrea, Ethiopia, Free State, Greece, Iran, Italy, Kenya, Kriti, KwaZulu-Natal, Lesotho, Libya, Madeira, Malawi, Mauritius, Morocco, Mozambique, Namibia, Nepal, Niger, Northern Provinces, Oman, Pakistan, Palestine, Portugal, Rwanda, Réunion, Sardegna, Saudi Arabia, Sicilia, Somalia, Spain, Sudan, Swaziland, Tanzania, Tunisia, Turkey, Turkey-in-Europe, Uganda, West Himalaya, Yemen, Yugoslavia, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Aromatase, CYP19A1 | |
| Gene or Protein evidence | These findings indicate that OLE has effective inhibitory action on aromatase at both the enzymatic and expression levels, in addition to its cytotoxic effect against MCF-7 cells. Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | These findings indicate that OLE has effective inhibitory action on aromatase at both the enzymatic and expression levels, in addition to its cytotoxic effect against MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:610675-1 | |
| Safety | NA |