| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-779 | |
| Phytochemical name or plant extracts | Oldenlandia diffusa extract | |
| PMID | 22213398 | |
| Literature evidence | Finally, we isolated ursolic and oleanolic acids as the bioactive compounds able to upregulate p53 expression and inhibit breast cancer cell growth. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hydro-alcholic extract | |
| Source of phytochemicals or plant Extracts | Oldenlandia diffusa | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Japan, Jawa, Korea, Lesser Sunda Is., Malaya, Myanmar, Nansei-shoto, Nepal, Nicobar Is., Philippines, Sri Lanka, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, p21WAF1/Cip1 | |
| Gene or Protein evidence | OD treatment increased p53 and p21WAF1/Cip1 protein expression in MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | 53.9 µg/ml against MCF-7 | |
| Potency | Our results evidence how OD, and its bioactive compounds, exert antiproliferative and apoptotic effects selectively in ERα-positive breast cancer cells, highlighting the potential use of these herbal extracts as breast cancer preventive and/or therapeutic agents. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In summary, we have demonstrated that OD treatment is effective in inhibiting the growth of ERα-positive and tamoxifen-resistant breast cancer cell lines, while it exhibits no effects in normal epithelial breast cells as well as in ERα-negative SKBR3 breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:757824-1 | |
| Safety | NA |