| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-100 | |
| Phytochemical name or plant extracts | Octyl gallate | |
| PMID | 29864945 | |
| Literature evidence | The present study was aimed to evaluate the effect of octyl gallate (OG) and gallic acid (GA) isolated from methanolic fruit extract of T. bellirica to inhibit the survival of breast cancer cells (MCF-7 & MDA-MB-231). | |
| IUPAC name | octyl 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Gallate ester | |
| Source of phytochemicals or plant Extracts | Terminalia bellirica | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, East Himalaya, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, Pakistan, Sri Lanka, Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, Cyclin D3, CDK-4, CDK-6, p18 INK4, p21Waf-1, p27 KIP, MRP2 | |
| Gene or Protein evidence | The compounds inhibited cell cycle progression by altering the expression of the cell cycle regulators (Cyclin D1, D3, CDK-4, CDK-6, p18 INK4, p21Waf-1 and p27 KIP). The pyrogallol moiety is also found in octyl gallate, which we found to inhibit MRP2. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Hence, both the compounds may serve as potential anticancer agents and could be developed as breast cancer drugs, with further explorations. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | The present investigation proved the downregulation of positive cell cycle regulators and upregulation of negative cell cycle regulators inducing apoptosis in compound-treated breast cancer cells. | |
| PubChem ID | 61253 | |
| Additional PMIDs | 28043125 29864945 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:170982-1 | |
| Safety | NA |