| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-393 | |
| Phytochemical name or plant extracts | Ocimum gratissimum extract | |
| PMID | 23380593 | |
| Literature evidence | Here we show that crude extract of Ocimum gratissimum (OG) and its hydrophobic and hydrophilic fractions (HB and HL) differentially inhibit breast cancer cell chemotaxis and chemoinvasion in vitro and retard tumor growth and temporal progression of MCF10ADCIS.com xenografts, a model of human breast comedo-ductal carcinoma in situ (comedo-DCIS). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Ocimum gratissimum | |
| Geographical availability | Aldabra, Andaman Is., Angola, Assam, Bangladesh, Botswana, Burundi, Cambodia, Cameroon, Caprivi Strip, Central African Repu, China Southeast, Comoros, Congo, Djibouti, Equatorial Guinea, Eritrea, Ethiopia, Gabon, Ghana, Guinea, Gulf of Guinea Is., India, Ivory Coast, Jawa, Kenya, KwaZulu-Natal, Laccadive Is., Laos, Liberia, Madagascar, Malawi, Malaya, Maldives, Mauritius, Mozambique, Namibia, Nepal, Nigeria, Northern Provinces, Rwanda, Senegal, Sierra Leone, Somalia, Sri Lanka, Sudan, Sumatera, Swaziland, Taiwan, Tanzania, Thailand, Togo, Uganda, Vietnam, Yemen, Zambia, Zaïre, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | MMP2, MMP9 | |
| Gene or Protein evidence | The MMP-2 and MMP-9 inhibitory activities of OG were verified in vitro using gelatin, a synthetic fluorogenic peptide and recombinant galectin-3 as MMP substrates. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | To summarize, we report on the identification of a natural, non-toxic inhibitor of human breast carcinoma progression through inhibition of MMP-2 and MMP-9 activities. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:452969-1 | |
| Safety | These data suggest that OG is non-toxic and that the anti-cancer therapeutic activity of OG may in part be contributed by its MMP inhibitory activity. |