| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1146 | |
| Phytochemical name or plant extracts | Ocimum basilicum (OB) extract | |
| PMID | 25554015 | |
| Literature evidence | OBL exhibited the highest antioxidant and antiproliferative activities. OB extracts not only improve taste but also have certain anticancer activity against diverse cancer cells due to the presence of compounds such as rosmarinic acid, chicoric acid and caftaric acid. Thus, OB represents a potent source of anticancer materials. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract and Methanolic extract | |
| Source of phytochemicals or plant Extracts | Ocimum basilicum | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, New Guinea, Nicobar Is., Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Cervical cancer, Pancreatic cancer | |
| Target gene or protein | AMPK | |
| Gene or Protein evidence | The treatment with both extracts also activated AMPK, but OB was much more efficient than OG in promoting this. | |
| Target pathways | Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway. The activation of mTOR signaling, another survival pathway was promoted by OB, whereas OG failed to activate it. | |
| IC50 | 250 µg/mL against MCF-7 | |
| Potency | In the end, we conclude that OB extract is efficient against the human breast cancer cell line. | |
| Cell line/ mice model | HeLa, MCF-7, Jurkat, HT-29, T24, MIAPaCa-2 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 29589262 33407904 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:452874-1 | |
| Safety | NA |