| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1604 | |
| Phytochemical name or plant extracts | Novel cold-water-soluble polysaccharide (BEP) | |
| PMID | 33507460 | |
| Literature evidence | In conclusion, our results demonstrated that BEP could inhibit the proliferation of breast cancer cells and induce apoptosis through mitochondrial pathways. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | The IR results showed that BEP was an acid polysaccharide, containing α-type and β-type glucoside bonds. | |
| Source of phytochemicals or plant Extracts | Boletus edulis | |
| Geographical availability | NA | |
| Plant parts | Mushroom | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, cyt-c, Caspase 3, Caspase 9 | |
| Gene or Protein evidence | Western blot results showed that BEP could increase the Bax/Bcl-2 ratios, promote the release of cytochrome C, and activate the expression of caspase-3 and caspase-9 in MDA-MB-231 and Ca761 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, our results demonstrated that BEP could inhibit the proliferation of breast cancer cells and induce apoptosis through mitochondrial pathways. | |
| Cell line/ mice model | MDA-MB-231 and Ca761 | |
| Additional information | Flow cytometry analysis revealed that BEP caused mitochondrial membrane potential collapse. Annexin V-FITC/PI staining indicated that BEP induced apoptosis of MDA-MB-231 and Ca761 cells through cell block in S phase and G0/G1 phase, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |