| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-938 | |
| Phytochemical name or plant extracts | Nordihydroguaiaretic acid (NDGA) | |
| PMID | 10490244 | |
| Literature evidence | Nordihydroguaiaretic acid exhibited a potent antioxidant activity in both HepG2 and MDA-MB-468 cells (IC50 5.3 and 1.1 microM respectively), as determined by inhibition of 2',7'-dichlorofluorescin oxidation via t-BOOH, although no inhibition was observed with other compounds tested in this system. | |
| IUPAC name | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Larrea divaricata | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Argentina South, Bolivia, Chile Central, Chile North, Peru | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | p16INK4a | |
| Gene or Protein evidence | Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest. | |
| Target pathways | NA | |
| IC50 | 1.1 μM against MDA-MB-468 | |
| Potency | The current study demonstrated that NDGA may modify the therapeutic effect of cisplatin in DMBA induced breast cancer in female Sprague-Dawley rats. | |
| Cell line/ mice model | HepG2, MDA-MB-468, T47D, RKO | |
| Additional information | The protective effect of NDGA against cisplatin induced nephrotoxicity in the rats was further confirmed by significant restoration of antioxidant enzymes like SOD (86.28% inhibition), inflammatory markers like TNF-α (34.6 pg/ml) and histopathological examination. | |
| PubChem ID | 4534 | |
| Additional PMIDs | 28043125 18472637 18164318 17103063 26247680 2224849 9066651 8313386 9849427 10490244 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:873316-1 | |
| Safety | NA |