| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1491 | |
| Phytochemical name or plant extracts | Nobiletin | |
| PMID | 22853317 | |
| Literature evidence | Neither proteasome inhibition nor lysosomal stabilization had any effect on the nobiletin-induced decrease in CXCR4 expression. | |
| IUPAC name | 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Arisaema franchetianum Engl , citrus fruits | |
| Geographical availability | Arisaema franchetianum Engl. - China South-Central, China Southeast, Myanmar, Vietnam | |
| Plant parts | Arisaema franchetianum Engl. tuber | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | CXCR4, MMP9, CYP1A1, CYP1B1 | |
| Gene or Protein evidence | Nobiletin down-regulated both the constitutive expressions of CXCR4 and MMP-9 in human breast cancer cells with IC(50) values of 32 and 24 µM, respectively. Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation. Nobiletin induced apoptosis and pyroptosis of BC cells via miR-200b/JAZF1/NF-κB axis. | |
| Target pathways | Moreover, nobiletin induced apoptosis and pyroptosis of BC cells via miR-200b/JAZF1/NF-kappaB axis. In conclusion, nobiletin inhibited the tumorigenesis of BC via regulation of miR-200b/JAZF1 axis. Thus, nobiletin might serve as a new agent for the treatment of BC. MAPK and Akt pathways, Nobiletin inhibited the tumorigenesis of BC via regulation of miR-200b/JAZF1 axis. | |
| IC50 | MTT assays in MCF7 cells further revealed that nobiletin exhibited significantly lower IC50 (44 µM) compared to cells treated with nobiletin and CYP1A1 inhibitor (69 µM). | |
| Potency | Our results indicate, for the first time, that nobiletin is a novel blocker of CXCR4 and MMP-9 expressions and thus has the potential to suppress metastasis of breast cancer. MTT assays in MCF7 cells further revealed that nobiletin exhibited significantly lower IC50 (44 µM) compared to cells treated with nobiletin and CYP1A1 inhibitor (69 µM). | |
| Cell line/ mice model | MCF-7, MDA-MB-231, H-29, Hs578T, BT-549 | |
| Additional information | Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to have inhibitory effects on tumorigenesis of cancers. These data indicate that, in these cell lines at concentrations that inhibit proliferation up to 80% over 4 days, tangeretin and nobiletin are cytostatic and significantly suppress proliferation by cell cycle arrest without apoptosis. 3. In summary, the present study is the first to report on the anticancer activities of 5,6,7,3',4',5'-hexamethoxyflavone and to provide evidence that this flavone could have a greater potential than nobiletin for prevention or treatment of triple- negative breast cancer. | |
| PubChem ID | 72344 | |
| Additional PMIDs | 22853317 28177754 33728753 23106482 29039514 22743247 25418056 17197076 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:85649-1 | |
| Safety | NA |