| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-403 | |
| Phytochemical name or plant extracts | Neotanshinlactone | |
| PMID | 21073172 | |
| Literature evidence | For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3, while the other four tanshinones (4-7) showed significant toxicity effects against all of the tested five cell lines. | |
| IUPAC name | 6,14-dimethyl-12,17-dioxatetracyclo[8.7.0.02,7.011,15]heptadeca-1(10),2,4,6,8,11(15),13-heptaen-16-one | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia digitaloides | |
| Geographical availability | China South-Central | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 4.07 μM against SKBR-3 | |
| Potency | For the bioassay to inhibit the growth of five tumor cell lines, neotanshinlactone (3) exhibited selective cytotoxic activity toward the human breast cancer cell line SK-BR-3 | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, SKBR-3, PANC-1 | |
| Additional information | NA | |
| PubChem ID | 10264769 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456106-1 | |
| Safety | NA |