| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1164 | |
| Phytochemical name or plant extracts | Neohesperidin | |
| PMID | 23285810 | |
| Literature evidence | Neohesperidin, a flavonoid compound found in high amounts in Poncirus trifoliata, has free radical scavenging activity. | |
| IUPAC name | (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Poncirus trifoliata | |
| Geographical availability | China North-Central, China South-Central, China Southeast | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax, Bcl-2 | |
| Gene or Protein evidence | The expressions of P53 and Bax in the neohesperidin-treated cells were significantly up-regulated, while that of Bcl-2 was down-regulated. | |
| Target pathways | Bcl-2/Bax-mediated signaling pathway | |
| IC50 | At 24h, 48h: 47.4 +/- 2.6 μM and 32.5 +/- 1.8 μM against MDA-MB-231 respectively. | |
| Potency | Our results indicated that the proliferation of MDA-MB-231 cells was inhibited by the treatment with neohesperidin in a time- and dose-dependent manner. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Compared to NH, HNPE showed higher anti-proliferative and pro-apoptotic in MCF-7 breast cancer cells, which may be explained by its increased lipophilicity compared to neohesperidin, benefiting to the action of NH on the cancer cell wall. | |
| PubChem ID | 442439 | |
| Additional PMIDs | 23562496 32984288 23285810 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:774884-1 | |
| Safety | NA |