| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-664 | |
| Phytochemical name or plant extracts | Nelumbo nucifera extract | |
| PMID | 27178635 | |
| Literature evidence | THE AIM OF THIS STUDY: The purpose of this study was to identify the hypothesis that NLE can suppress tumor angiogenesis and metastasis through CTGF (connective tissue growth factor), which has been implicated in tumor angiogenesis and progression in breast cancer MDA-MB-231 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract Alcohol extract | |
| Source of phytochemicals or plant Extracts | Nelumbo nucifera | |
| Geographical availability | Amur, Assam, Bangladesh, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Iran, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Manchuria, Myanmar, Nepal, New Guinea, North Caucasus, Northern Territory, Pakistan, Philippines, Primorye, Queensland, South European Russi, Sri Lanka, Thailand, Transcaucasus, Ukraine, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | CTGF | |
| Gene or Protein evidence | Nelumbo nucifera Gaertn leaves extract inhibits the angiogenesis and metastasis of breast cancer cells by downregulation connective tissue growth factor (CTGF) mediated PI3K/AKT/ERK signaling | |
| Target pathways | PI3K/AKT/ERK signaling TGF-β1/Erk1/2 pathway TGF-β1/SMAD3 signaling pathway | |
| IC50 | NA | |
| Potency | The present results suggest that NLE might be useful for treatment in therapy-resistance triple negative breast cancer. | |
| Cell line/ mice model | MDA-MB-231, SKBR-3, HCC1806 | |
| Additional information | In Xenograft model, NLE treatment significantly reduced tumor weight and CD31 (capillary density) over control, respectively. We demonstrated that LAE had the potential inhibitory activity for cell migration and EMT in vitro and in vivo. | |
| PubChem ID | NA | |
| Additional PMIDs | 24929106 31207222 34820007 33602253 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:605422-1 | |
| Safety | NA |