| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1144 | |
| Phytochemical name or plant extracts | Neferine (NEF) | |
| PMID | 31207222 | |
| Literature evidence | Our study designed to check the effect of NEF on breast cancer MDA-MB-231 cells and further explore the potential mechanism. | |
| IUPAC name | 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Nelumbo nucifera | |
| Geographical availability | Amur, Assam, Bangladesh, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Iran, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Manchuria, Myanmar, Nepal, New Guinea, North Caucasus, Northern Territory, Pakistan, Philippines, Primorye, Queensland, South European Russi, Sri Lanka, Thailand, Transcaucasus, Ukraine, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Seeds embryo | |
| Other cancers | Breast cancer | |
| Target gene or protein | miR-374a/FGFR-2 | |
| Gene or Protein evidence | We found that NEF possessed the anti-growth and anti-metastasis effect on MDA-MB-231 cells through regulating miR-374a/FGFR-2, which might provide new insight for breast cancer management. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Our observations might provide fundamental experiments basis for the anti-tumor activity of NEF and suggested that NEF might be a potential agent for breast cancer management. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Finally, it was revealed that neferine was involved in the inhibition of Nrf2, an antioxidant factor. | |
| PubChem ID | 159654 | |
| Additional PMIDs | 32705225 31207222 12579872 34273439 23742976 26219228 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:605422-1 | |
| Safety | NA |