| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1596 | |
| Phytochemical name or plant extracts | Naringin | |
| PMID | 33192517 | |
| Literature evidence | These experimental results showed that Balsamin combined with flavonoids can reduce HepG2 and MCF-7 cells viability and induce apoptosis, which could be considered as a promising therapeutic approach to sensitize cells to Balsamin treatment, thereby improving its efficacy in breast or liver cancer therapy. | |
| IUPAC name | (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Rhizoma drynariae | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21, Survivin | |
| Gene or Protein evidence | Our data demonstrated that naringin inhibited cell proliferation, and promoted cell apoptosis and G1 cycle arrest, accompanied by increased p21 and decreased survivin. | |
| Target pathways | β-catenin signaling pathway | |
| IC50 | NA | |
| Potency | Taken together, these results indicate that naringin could inhibit growth potential of TNBC cells by modulating β-catenin pathway, which suggests naringin might be used as a potential supplement for the prevention and treatment of breast cancer. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 xenograft mice | |
| Additional information | In contrast, over-expressing β-catenin by adenoviral vector system in TNBC cells reversed the antitumor activity of naringin, and regulated p21 and survivin. | |
| PubChem ID | 442428 | |
| Additional PMIDs | 23694763 21964193 29375370 | |
| Additional sources of information | NA | |
| Safety | NA |