| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1876 | |
| Phytochemical name or plant extracts | Myricetin | |
| PMID | 27249025 | |
| Literature evidence | The use of small molecules to arrest G-quadruplex structure has become a potential strategy for the development and design of a new class of anticancer therapeutics. | |
| IUPAC name | 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Polyphenol Flavonoid | |
| Source of phytochemicals or plant Extracts | Withania coagulans | |
| Geographical availability | Afghanistan, India, Iran, Nepal, Oman, Pakistan | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, BRCA1, GADD45, Bax, Bcl-2 | |
| Gene or Protein evidence | The expression rate of apoptotic genes caspase-3, caspase-8, caspase-9, the ratio of BAX /Bcl-2 as well as the expression of P53, BRCA1, GADD45 genes were increased significantly after treatment of T47D breast cancer cells with myricetin. | |
| Target pathways | Myricetin Exerts its Apoptotic Effects on MCF-7 Breast Cancer Cells through Evoking the BRCA1-GADD45 Pathway. Myricetin Inhibits Breast Tumor Growth and Angiogenesis by Regulating VEGF/VEGFR2 and p38MAPK Signaling Pathways. Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway. Myricetin enhances apoptosis in T47D breast cancer cells by evoking both extrinsic and intrinsic apoptotic pathways. myricetin may practices its apoptotic properties on T47D cells through inducing BRCA1- GADD45 pathway. | |
| IC50 | 14.75 μM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, T47D, MDA-MB-231 | |
| Additional information | Myricetin also induced hydrogen peroxide (H2O2) production in cell-free culture medium, as well as in the presence of TNBC cells and normal cells. | |
| PubChem ID | 5281672 | |
| Additional PMIDs | 33369440 31266091 29742465 27122002 33369470 29579978 29984179 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:821678-1 | |
| Safety | NA |