| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2072 | |
| Phytochemical name or plant extracts | Muscadine grape skin extract (MSKE) | |
| PMID | 26069256 | |
| Literature evidence | Therefore, inhibition using a natural product such as MSKE could potentially be a promising bioactive compound for bone metastatic cancer. © The Author 2015. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Vitis rotundifolia | |
| Geographical availability | Alabama, Arkansas, Bahamas, Delaware, Florida, Georgia, Kentucky, Louisiana, Maryland, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southwest, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, West Virginia | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Prostate cancer | |
| Target gene or protein | Snail, pSTAT-3 | |
| Gene or Protein evidence | MSKE decreased Snail and pSTAT3 expression, and abrogated Snail-mediated CatL activity, migration and invasion. Additionally, Snail overexpression promoted osteoclastogenesis, which was significantly inhibited by the MSKE as effectively as Z-FY-CHO, a CatL-specific inhibitor, or osteoprotegerin, a receptor activator of nuclear factor kappa B ligand (RANKL) antagonist. | |
| Target pathways | STAT-3 signaling | |
| IC50 | NA | |
| Potency | Overall, these novel findings suggest that Snail regulation of CatL may occur via STAT-3 signaling and can be antagonized by MSKE, leading to decreased cell invasion, migration and bone turnover. Therefore, inhibition using a natural product such as MSKE could potentially be a promising bioactive compound for bone metastatic cancer. | |
| Cell line/ mice model | NA | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:308496-2 | |
| Safety | NA |