| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-233 | |
| Phytochemical name or plant extracts | Muscadine grape extract (MGE) | |
| PMID | 32578460 | |
| Literature evidence | Studies showed that isolated polyphenols or polyphenol-rich muscadine grape extracts polyphenols inhibit the proliferation of various cancer cells including breast cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Polyphenolic extract | |
| Source of phytochemicals or plant Extracts | Vitis rotundifolia | |
| Geographical availability | Alabama, Arkansas, Bahamas, Delaware, Florida, Georgia, Kentucky, Louisiana, Maryland, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southwest, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, West Virginia | |
| Plant parts | Seeds and skin | |
| Other cancers | Breast cancer | |
| Target gene or protein | c-met, Cyclin D1 | |
| Gene or Protein evidence | MGE reduced c-Met, differentially abrogated ERK/MAPK and AKT signaling, and decreased a downstream targets of ERK/MAPK and AKT pathways, cyclin D1. | |
| Target pathways | ERK/MAPK and AKT signaling | |
| IC50 | NA | |
| Potency | The pluripotency of MGE and high index of safety and tolerability suggest that the extract may serve as a therapeutic to reduce TNBC progression to metastatic disease. | |
| Cell line/ mice model | Mouse 4T1, MDA-MB-231, BT-549 | |
| Additional information | Our results demonstrated that the MGE used in our preclinical and clinical studies appears to be safe and well-tolerated, MGE effectively reduced tumor growth in mice and inhibited oncogenic signaling in TNBC cells. This suggests that the extract may be an effective nutraceutical as an adjuvant to standard of care to treat women with TNBC. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:308496-2#synonyms | |
| Safety | NA |