| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-798 | |
| Phytochemical name or plant extracts | Murraya koenigii leaf extract | |
| PMID | 23302496 | |
| Literature evidence | Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Murraya koenigii | |
| Geographical availability | Assam, Bangladesh, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Laos, Malaya, Nepal, Pakistan, Sri Lanka, Thailand, Vietnam, West Himalaya | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | CLE decreased cell viability and altered the growth kinetics in both the breast cancer cell lines in a dose-dependent manner. It showed a significant arrest of cells in the S phase albeit in cancer cells only. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Annexin V binding data suggests that cell death was via the apoptotic pathway in both the cancer cell lines. CLE treatment significantly decreased the activity of the 26S proteasome in the cancer but not normal cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:774433-1 | |
| Safety | NA |