| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-210 | |
| Phytochemical name or plant extracts | Mulberry leaf lectin | |
| PMID | 22982777 | |
| Literature evidence | Cells were treated with GI(50) concentration (concentration of lectin required for 50% inhibition of cell growth) of MLL (8.5 μg/ml for MCF-7 and 16 μg/ml for HCT-15) for 24 h to induce cell death. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Lectin | |
| Source of phytochemicals or plant Extracts | Morus alba | |
| Geographical availability | China North-Central, China South-Central | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | Caspase 3 | |
| Gene or Protein evidence | Up-regulation of caspase 3 activity was also found in cells treated with MLL. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Cells were treated with GI(50) concentration (concentration of lectin required for 50% inhibition of cell growth) of MLL (8.5 μg/ml for MCF-7 and 16 μg/ml for HCT-15) for 24 h to induce cell death. | |
| Cell line/ mice model | MCF-7, HCT-15 | |
| Additional information | Flow cytometry analysis showed an increase in the percentage of cells in sub G0-G1 phase confirming the MLL induced apoptosis. In conclusion, MLL induced apoptosis in MCF-7 and HCT-15 cells in a caspase dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30051955-2 | |
| Safety | NA |