| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-387 | |
| Phytochemical name or plant extracts | Motherwort extract | |
| PMID | 19330917 | |
| Literature evidence | CONCLUSIONS: These data suggest that Chinese motherwort aqueous ethanol extract may effectively inhibit the proliferation of breast cancer cells through mechanisms of both cytotoxicity and cell cycle arrest. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Leonurus japonicus | |
| Geographical availability | Amur, Assam, Bangladesh, Borneo, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, India, Inner Mongolia, Japan, Jawa, Khabarovsk, Korea, Laos, Lesser Sunda Is., Malaya, Maluku, Manchuria, Myanmar, Nansei-shoto, Nepal, Philippines, Primorye, Qinghai, Queensland, Sulawesi, Sumatera, Taiwan, Thailand, Tibet, Vietnam, West Himalaya, Xinjiang | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | At 24h : 96.2 µg/mL against MCF-7 89.1 µg/mL against MDA-MB-231 At 48h : 67.7 µg/mL against MCF-7 53.4 µg/mL against MDA-MB-231 | |
| Potency | Chinese motherwort aqueous extract (MAE)was previously reported to have anti-cancer activity in breast cancer cells with low potency (IC50s in a range of 8-40 mg/mL). | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | These data suggest that Chinese motherwort aqueous ethanol extract may effectively inhibit the proliferation of breast cancer cells through mechanisms of both cytotoxicity and cell cycle arrest. The cellular effects of MAEE are non-apoptotic and ER independent on breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:449195-1 | |
| Safety | NA |