| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2089 | |
| Phytochemical name or plant extracts | Morusin | |
| PMID | 34578920 | |
| Literature evidence | Plants are valuable sources of natural polyphenolic compounds with isoprenyl groups, which include flavones, flavanones, chalcones and aurones. | |
| IUPAC name | 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Morus alba | |
| Geographical availability | China North-Central, China South-Central | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Liver cancer, Lung cancer, Glioma, Prostate cancer, Pancreatic cancer, Stomach cancer | |
| Target gene or protein | E-cadherin, Vimentin, α2-, α6-, β1- integrin, MMP2, MMP9, iNOX, COX | |
| Gene or Protein evidence | Morusin also increased the expression of E-cadherin, an epithelial cell junction protein, decreased the expression of vimentin, a mesecnchymal marker, and α2-, α6-, β1- integrin, which regulated cancer attachment and migration. In addition, morusin reduced the activity of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9), which were involved in extracellular matrix (ECM) degradation and promoting cancer cell invasion. It also inhibits the inflammatory response by suppressing COX activity and iNOS expression. | |
| Target pathways | signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NF-κB) signaling pathways | |
| IC50 | 40.78 ± 1.51 μM against MCF-7 | |
| Potency | Finally, morusin decreased the lung colonization of the SK-Hep1 cells in the nude mice. These results indicate morusin possesses antitumor progression potential through suppressing STAT3 and NFκB. | |
| Cell line/ mice model | MCF-7, A549, HepG2, MDA-MB-231 | |
| Additional information | The research carried out so far revealed that morusin has antioxidant, antitumor, anti-inflammatory and anti-allergic activity. Moreover, its neuroprotective and antihyperglycemic properties have also been confirmed. Morusin suppresses the growth of different types of tumors, including breast cancer, glioblastoma, pancreatic cancer, hepatocarcinoma, prostate cancer, and gastric cancer. Moreover, an antimicrobial effect against Gram-positive bacteria was observed after treatment with morusin. | |
| PubChem ID | 5281671 | |
| Additional PMIDs | 25476160 30822142 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30051955-2 | |
| Safety | NA |