| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-633 | |
| Phytochemical name or plant extracts | Morin | |
| PMID | 31049822 | |
| Literature evidence | Collectively, our data suggest that morin can induce apoptosis of melanoma cells by regulating pro-apoptotic and anti-apoptotic proteins through ROS, and may be a potential substance for treatment of melanoma. | |
| IUPAC name | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Psidium guajava Cudranaia tricuspidata | |
| Geographical availability | Argentina Northeast, Argentina Northwest, Bolivia, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Colombia, Ecuador, Paraguay, Peru, Venezuela | |
| Plant parts | Leaves of Cudranaia tricuspidata | |
| Other cancers | Breast cancer | |
| Target gene or protein | RAD51, H2AA.X, Caspase 3, Caspase 7, p38, JNK, PARP | |
| Gene or Protein evidence | Morin also induced the phosphorylation of H2A.X and downregulated the expression levels of RAD51 and survivin, which implied morin‑induced DNA damage and that this damage accumulated in HER‑2‑overexpressing SK‑BR‑3 cells. Western blot analysis and fluorescent immunocytochemisty showed that morin also activated autophagy after 24 h of treatment and this was maintained at 48 h when activation of apoptosis via PARP cleavage resulted in the activation of caspase‑3 and ‑7, which was associated with the release of cytochrome c to the cytosol from mitochondria. In addition, the phosphorylation of p38 and JNK was enhanced in the HER‑2‑overexpressing SK‑BR‑3 cells by morin after 24 and 48 h of treatment, which suggested p38 and JNK participate in morin‑induced cell death. | |
| Target pathways | HER2/EGFR signaling pathway | |
| IC50 | NA | |
| Potency | The present investigation indicates that morin is a powerful therapeutic candidate for the treatment of HER2‑overexpressing breast cancer because it suppresses the EGFR signaling pathway, induces cell death by inhibiting the HER2/EGFR signaling pathway, and suppresses metastatic potential. | |
| Cell line/ mice model | SKBR‑3 | |
| Additional information | Morin induced ROS production and apoptosis, as presented by increased proportion of cells with Annexin V-PE(+) staining and sub-G0/G1 peak in cell cycle analysis. It also downregulated Sp1, Mcl-1, Bcl-2, and caspase-3 but upregulated cleaved caspase-3, Bax, and PUMA. In immunohistochemical staining, Sp1 was overexpressed in melanoma tissues compared to normal skin tissues. Collectively, our data suggest that morin can induce apoptosis of melanoma cells by regulating pro-apoptotic and anti-apoptotic proteins through ROS, and may be a potential substance for treatment of melanoma. | |
| PubChem ID | 5281670 | |
| Additional PMIDs | 33982761 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:600841-1 | |
| Safety | NA |