| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-212 | |
| Phytochemical name or plant extracts | Moracin O | |
| PMID | 33173971 | |
| Literature evidence | The aim of the present study was to identify natural anti‑inflammatory products that can target NF‑κB activity, in order to establish a novel therapeutic approach for inflammatory diseases. | |
| IUPAC name | 5-[6-(2-hydroxypropan-2-yl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Benzopyran | |
| Source of phytochemicals or plant Extracts | Morus alba | |
| Geographical availability | China North-Central, China South-Central | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | BCL‑XL, Bcl‑2, p65 subunit of NF‑κB | |
| Gene or Protein evidence | Moreover, Sohakuhi treatment also upregulated the anti‑apoptotic proteins Bcl‑xL and Bcl‑2. While TRAIL triggered the phosphorylation of the p65 subunit of NF‑κB, leading to cellular damage in HaCaT cells, treatment with Sohakuhi extract protected HaCaT cells against TRAIL‑induced cellular damage. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Importantly, through chemical fractionation of Sohakuhi extract, moracin O and P were confirmed to mediate its anti‑inflammatory effects. Collectively, the present results indicated that Sohakuhi and moracin may represent potential candidates for the development of novel anti‑inflammatory drugs. | |
| Cell line/ mice model | 4T1 | |
| Additional information | Using a 4T1 breast cancer cell line that expresses the firefly luciferase gene under the control of an NF‑κB response element, 112 natural products were tested for their anti‑inflammatory properties. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30051955-2 | |
| Safety | NA |