| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-783 | |
| Phytochemical name or plant extracts | Mollugin | |
| PMID | 23065756 | |
| Literature evidence | Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression. | |
| IUPAC name | methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate | |
| Phytochemicals’ class or type of plant extracts | Naphthohydroquine | |
| Source of phytochemicals or plant Extracts | Rubia cordifolia | |
| Geographical availability | Afghanistan, Amur, Angola, Assam, Bangladesh, Borneo, Burundi, Buryatiya, Cape Provinces, China North-Central, China South-Central, China Southeast, Chita, East Himalaya, Ethiopia, Free State, Greece, India, Inner Mongolia, Japan, Jawa, Kenya, Khabarovsk, Korea, KwaZulu-Natal, Malawi, Malaya, Mongolia, Mozambique, Myanmar, Nepal, Northern Provinces, Pakistan, Primorye, Qinghai, Rwanda, Somalia, Sri Lanka, Sudan, Sumatera, Swaziland, Taiwan, Tanzania, Tibet, Uganda, Vietnam, West Himalaya, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Ovarian cancer | |
| Target gene or protein | FAS | |
| Gene or Protein evidence | Furthermore, we found that a blockade of Akt/SREBP-1c signaling through mollugin treatment significantly reduced FAS expression and subsequently suppressed cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. | |
| Target pathways | Mollugin inhibits proliferation and induces apoptosis in HER2-overexpressing cancer cells by blocking expression of the FAS gene through modulation of a HER2/Akt/SREBP-1c signaling pathway. | |
| IC50 | 121μM against MCF-7 | |
| Potency | Our findings suggest that mollugin is a novel modulator of the HER2 pathway in HER2-overexpressing cancer cells with a potential role in the treatment and prevention of human breast and ovarian cancer with HER2 overexpression. | |
| Cell line/ mice model | SKBR-3 , SK-OV-3 | |
| Additional information | Mollugin treatment caused a dose-dependent inhibition of HER2 gene expression at the transcriptional level, potentially in part through suppression of NF-κB activation. | |
| PubChem ID | 124219 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:765218-1 | |
| Safety | NA |