| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1496 | |
| Phytochemical name or plant extracts | Mistletoe extract (PS76A2) | |
| PMID | 15154663 | |
| Literature evidence | The standardised mistletoe extract PS76A2 improves QoL in patients with breast cancer receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Viscum album | |
| Geographical availability | Albania, Algeria, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, China South-Central, Corse, Czechoslovakia, Denmark, East European Russia, East Himalaya, France, Germany, Great Britain, Greece, Hungary, Iran, Italy, Kriti, Krym, Lebanon-Syria, Morocco, Myanmar, Nepal, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Poland, Portugal, Romania, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, Vietnam, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Skin cancer, Myosarcoma, Colon cancer | |
| Target gene or protein | TNF, H2A histone family member X, Plasminogen | |
| Gene or Protein evidence | Simultaneous treatment of human cervix carcinoma HeLa or breast carcinoma MCF-7 cells with MLs isolated from European or Korean mistletoe rendered them more sensitive to induction of apoptosis by TNF. In all supernatants of AM-stimulated cell culture TNF-alpha and IL-6 were found, Indicating activation of cells of the monocyte/macrophage lineage by mistletoe extracts. Mistletoe extract simultaneously increased the expression of the DNA damage marker proteins, phosphorylated H2A histone family member X (H2A.X), and phosphorylated p38.In addition to tumor growth inhibition, mistletoe extract inhibited lung metastasis in the tumor-bearing mice and cell invasiveness by downregulating the expressions of matrix metalloproteinases (MMPs), urokinase-type plasminogen activator (uPA), uPA receptor, and markers of epithelial-mesenchymal transition (snail and fibronectin). | |
| Target pathways | Mistletoe extract targets the STAT3-FOXM1 pathway for its cytotoxic effect. | |
| IC50 | NA | |
| Potency | Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. | |
| Cell line/ mice model | MCF-7, HT-144, SK-MEL-28, SK-MLS-1, S-UT-1B, Kpl-1, Mfm-223 | |
| Additional information | Therefore, the objective of this clinical study was to investigate the impact of PS76A2, an aqueous mistletoe extract standardised to the galactoside-specific mistletoe lectin, on QoL by performing a placebo-controlled trial. As a result, statistically significant effects on QoL were obtained with the medium dose (15 ng ML/0.5 ml). The treatment difference between the medium dose and placebo with regard to the GLQ-8 sum was 60.8 mm (95% confidence interval: 19.3 to 102.0 mm). The treatment effect for Spitzer's uniscale between the medium dose and placebo was 16.4 mm (95% confidence interval: 6.3 to 26.6 mm). The results on QoL were supported by an increase of T helper lymphocytes (CD4+) and the CD4+/CD8+ ratio (p<0.05). Overall, PS76A2 was well tolerated. Local reactions at the injection sites occurred dose-dependently, but were mild at the low and medium dose levels. | |
| PubChem ID | NA | |
| Additional PMIDs | 15219134 15154645 14981970 15154663 15353899 14666680 16927530 16619567 21289969 16927532 17695469 18383896 21556248 19295230 33622211 8067703 9010693 9533928 24876872 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:300881-2 | |
| Safety | NA |