| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-424 | |
| Phytochemical name or plant extracts | Methyl linderone (ML) | |
| PMID | 31893611 | |
| Literature evidence | Therefore, ML is a potential agent for the treatment of breast cancer metastasis. | |
| IUPAC name | 4,5-dimethoxy-2-[(E)-1-methoxy-3-phenylprop-2-enylidene]cyclopent-4-ene-1,3-dione | |
| Phytochemicals’ class or type of plant extracts | Pentenedione | |
| Source of phytochemicals or plant Extracts | Lindera erythrocarpa | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Korea, Taiwan | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3, AP-1, MMP9, IL-8 | |
| Gene or Protein evidence | The TPA-stimulated nuclear translocation of AP-1 and STAT3 was attenuated by ML, suggesting that AP-1 and STAT3 are the main transcription factors involved in the signaling pathway regulated by ML. ML significantly downregulated MMP-9 and IL-8 expression in TPA-stimulated MCF7 cells, by inhibiting the ERK/STAT3/AP-1-mediated signaling pathway. | |
| Target pathways | ERK/STAT3/AP-1-mediated signaling pathway | |
| IC50 | NA | |
| Potency | These results suggested that ML is a potential pharmacological agent for breast cancer treatment, to block cancer invasion and migration. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 10086155 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:465359-1 | |
| Safety | NA |