| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1132 | |
| Phytochemical name or plant extracts | Methyl jasmonate | |
| PMID | 18690087 | |
| Literature evidence | MJ also decreased the mitochondrial membrane potential and activated caspase-3 in breast cancer cells. | |
| IUPAC name | methyl 2-[(1R,2R)-3-oxo-2-[(Z)-pent-2-enyl]cyclopentyl]acetate | |
| Phytochemicals’ class or type of plant extracts | Methyl ester | |
| Source of phytochemicals or plant Extracts | Lonicera japonica | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Korea, Manchuria, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | Caspase 3, PAL | |
| Gene or Protein evidence | MJ also decreased the mitochondrial membrane potential and activated caspase-3 in breast cancer cells. Compared with control plants, MeJA-treated sweet potato exhibited the highest PAL activity, followed by SA and ABA treatment. | |
| Target pathways | Cellular signaling studies with MJ showed decreased membrane fluidity and activation of extrinsic and intrinsic apoptotic pathways. Specifically in extrinsic apoptotic pathway increased expression of TNF receptor 1, activation of mitogen-activated protein kinase and caspase-8 was observed. | |
| IC50 | 1.2 mM against MDA-MB-435 1.45 mM against MCF-7 | |
| Potency | In conclusion our results revealed novel-signaling mechanism of MJ in breast cancer cells, indicating that MJ could have potential applications for chemotherapeutic purposes. | |
| Cell line/ mice model | MDA-MB-435, MCF-7, A549 | |
| Additional information | Herein we show that methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via reactive oxygen species production in A549 human lung adenocarcinoma cells. | |
| PubChem ID | 5281929 | |
| Additional PMIDs | 27234523 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:148850-1 | |
| Safety | CJ and MJ were not cytotoxic to CDC-1070-SK and MCF-10A normal cells |