| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1865 | |
| Phytochemical name or plant extracts | Methyl caffeate | |
| PMID | 26415618 | |
| Literature evidence | Methyl caffeate significantly reduced cell proliferation and increased formation of fragmented DNA and apoptotic body in MCF-7 cells. | |
| IUPAC name | methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Alkyl caffeate ester | |
| Source of phytochemicals or plant Extracts | Solanum torvum | |
| Geographical availability | Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Colombia, Ecuador, French Guiana, Guyana, Nicaragua, Panamá, Peru, Suriname, Trinidad-Tobago, Venezuela | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer, Liver cancer, Colon cancer | |
| Target gene or protein | Bcl-2, Bid, Bax, cyt-c | |
| Gene or Protein evidence | Bcl-2 protein was down regulated, Bid and Bax were up regulated after the treatment with methyl caffeate. The results strongly suggested that methyl caffeate induced apoptosis in MCF-7 cells via caspase activation through cytochrome c release from mitochondria. | |
| Target pathways | NA | |
| IC50 | 0.62 μΜ for 24h against MCF-7 | |
| Potency | The compound showed potent cytotoxic properties against MCF-7 cells compared to A549, COLO320 and HepG-2 cells. | |
| Cell line/ mice model | MCF-7, A549, COLO320, HepG-2, Vero | |
| Additional information | Methyl caffeate treated diabetic rats showed upregulation of GLUT4 and regeneration of β-cells in the pancreas. These results substantiated that methyl caffeate possessed hypoglycemic effect, and it could be developed into a potent oral antidiabetic drug. | |
| PubChem ID | 689075 | |
| Additional PMIDs | 21963451 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:821288-1 | |
| Safety | NA |