| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1784 | |
| Phytochemical name or plant extracts | Methyl antcinate A | |
| PMID | 22753732 | |
| Literature evidence | In addition to MAA, methyl antcinate B, dehydroeburicoic acid, and 15α-acetyl-dehydrosulfurenic acid also exhibited significant selective cytotoxic effects to respective cancer cells. | |
| IUPAC name | methyl (6R)-6-[(6S,11aR)-6,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9H,9aH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-methyl-3-methylideneheptanoate | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Antrodia camphorata, Antrodia cinnamomea | |
| Geographical availability | Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Oral cancer, Epithelioid cancer, Prostate cancer, Ovarian cancer, Cervical cancer, Bone cancer, Stomach cancer | |
| Target gene or protein | Bax, Bak, PUMA. | |
| Gene or Protein evidence | MAA can also up-regulate Bax, Bak, PUMA, and mitochondrial translocation of cofilin, activate caspase-3 and lead to cell death | |
| Target pathways | Exerts cell death through the caspase-dependent cascade and the Bax-mediated mitochondrial apoptotic pathway Suppresses the expression of heat shock protein 27 and increases the expression of IkBα and p53 3. MAA induces apoptosis in human liver and oral cancer cells through the mitochondrial-dependent pathway . | |
| IC50 | 29.0 μM against BT474 | |
| Potency | Our previous study in a liver cancer model showed that MAA, compound 11, which has more potent cytotoxic effects than Ant A and Ant C, may exert its anticancer capability via inducing ROS generation and NADPH oxidase activation | |
| Cell line/ mice model | KB, TSCCa, GNM, OC-2, and OEC-M1 , Panc-1 , BT-474, PC-3, OVCAR-3, HeLa, and U2OS, ER+ T47D | |
| Additional information | Shows good inhibitory effects on the self-renewal capability and cell migration ability of MCF7 sphere cells | |
| PubChem ID | NA | |
| Additional PMIDs | 23442930 | |
| Additional sources of information | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095428/ | |
| Safety | NA |