| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-995 | |
| Phytochemical name or plant extracts | Methyl angolensate | |
| PMID | 23675192 | |
| Literature evidence | We also find that MA activates MAP kinase pathway to induce apoptosis. | |
| IUPAC name | methyl 2-[13-(furan-3-yl)-6,6,8,12-tetramethyl-17-methylidene-5,15-dioxo-2,14-dioxatetracyclo[7.7.1.01,12.03,8]heptadecan-7-yl]acetate | |
| Phytochemicals’ class or type of plant extracts | Tetranortriterpenoid | |
| Source of phytochemicals or plant Extracts | Soymida febrifuga | |
| Geographical availability | Bangladesh, India, Myanmar, Sri Lanka | |
| Plant parts | Root callus | |
| Other cancers | Breast cancer | |
| Target gene or protein | KU70, KU80 | |
| Gene or Protein evidence | Western blot analyses have showed that upon treatment with MA, the levels of KU70 and KU80 increased for first two days (upto 48 h). However, treatment upto 72 h led to the downregulation of KU proteins | |
| Target pathways | MAP kinase pathway | |
| IC50 | 90 μM against T47D | |
| Potency | MA treatment led to the inhibition of cell proliferation as detected by tritiated thymidine assay and flowcytometry. Further, MA treated cells exhibited typical apoptotic morphological changes and led to the accumulation of subG1 peak in cell cycle distribution. | |
| Cell line/ mice model | T47D | |
| Additional information | These results suggest that MA induces cytotoxicity in breast cancer cells. Further, the altered expression of DSB repair proteins in MA treated cells may control the induction of apoptosis in these cancer cells. | |
| PubChem ID | 419676 | |
| Additional PMIDs | 24342110 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:941499-1 | |
| Safety | NA |