| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-617 | |
| Phytochemical name or plant extracts | Meso-dihydroguaiaretic acid (MDGA) | |
| PMID | 11731908 | |
| Literature evidence | Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. | |
| IUPAC name | 4-[(2S,3R)-4-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Myristica argentea | |
| Geographical availability | New Guinea | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | EGFR,Src, CDK-4, cyclin D1, integrin β3 | |
| Gene or Protein evidence | MDA inhibits cell migration and dephosphorylates EGFR and Src in 4T-1 cells. MDA-induced down-regulation of CDK-4, cyclin D1, EGFR and integrin β3 is dependent on p38 activation but not JNK in 4T-1 cells. | |
| Target pathways | NA | |
| IC50 | 65.4 µM against MCF-7 | |
| Potency | Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. | |
| Cell line/ mice model | MCF-7, 4T1, HT-29 | |
| Additional information | The natural product MDGA is thus an attractive template to develop new anti-tuberculosis drugs, because its target is different from those of known anti-tubercular agents. | |
| PubChem ID | 476856 | |
| Additional PMIDs | 15256759 11731908 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:585972-1 | |
| Safety | NA |