| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-207 | |
| Phytochemical name or plant extracts | Mentha arvensis extract | |
| PMID | 28458579 | |
| Literature evidence | CONCLUSION: GSNPs synthesized using Mentha arvensis may be considered as a promising anticancer agent in breast cancer therapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Aqueous extract | |
| Source of phytochemicals or plant Extracts | Mentha arvensis | |
| Geographical availability | Afghanistan, Altay, Austria, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, Czechoslovakia, Denmark, East European Russia, Finland, France, Føroyar, Germany, Great Britain, Greece, Hungary, Iceland, India, Ireland, Irkutsk, Italy, Kamchatka, Kazakhstan, Kirgizstan, Krasnoyarsk, Magadan, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Primorye, Romania, South European Russi, Spain, Svalbard, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Turkey, Turkmenistan, Tuva, Ukraine, Uzbekistan, West Himalaya, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Colon cancer, Glioma, Lung cancer, Leukemia, Prostate cancer | |
| Target gene or protein | PARP1, p53, P21, Bax, Bcl-2, Caspase 9 | |
| Gene or Protein evidence | Upregulation of PARP1, P53, P21, Bax and cleaved caspase 9 was observed in MCF7 cells after GSNPs treatment, whereas Bcl2 was downregulated. Cleaved bands of PARP1 were prominent at 24 and 48 h after treatment with GSNPs. In MDA-MB-231 cells, the mutant P53 protein was downregulated, whereas PARP1, P53, P21, Bax, cleaved caspase 9 and both procaspase 3 and cleaved caspase 3 proteins were upregulated. Cleavage of PARP1 protein was noticed 2 h onward, which was prominent at 8 and 48 h. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | GSNPs synthesized using Mentha arvensis may be considered as a promising anticancer agent in breast cancer therapy. They are less toxic and nonmutagenic and mediate caspase 9-dependent apoptosis in MCF7 and MDA-MB-231 cells. | |
| Cell line/ mice model | MDA-MB-231, A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1, U-87MG | |
| Additional information | Expression patterns of proteins suggested that GSNPs triggered caspase 9-dependent cell death in both cell lines. The Ames test showed that GSNPs were nonmutagenic in nature. | |
| PubChem ID | NA | |
| Additional PMIDs | 25630112 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30026217-2 | |
| Safety | NA |