| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-76 | |
| Phytochemical name or plant extracts | Matricaria chamomilla extract | |
| PMID | 28250660 | |
| Literature evidence | SUMMARY: Antioxidant compounds in Matricaria chamomilla have anticancer effects.Hydroalcoholic extract of M. chamomilla controls cellular proliferation and apoptosis induction.Hoechst 33342/propidium iodide staining suggested that the extract induces apoptosis more than necrosis.Hydroalcoholic extract of M. chamomilla prevents colonization and cellular migration of human breast cancer MDA-MB-468 and MCF-7 cell lines in a time- and dose-dependent manner.M. chamomilla has low cytotoxic effects on natural cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hydroalcoholic extract | |
| Source of phytochemicals or plant Extracts | Matricaria chamomilla | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Azores, Belarus, Belgium, Bulgaria, Buryatiya, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Egypt, Finland, France, Germany, Greece, Hungary, India, Iran, Iraq, Irkutsk, Italy, Kazakhstan, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Lebanon-Syria, Manchuria, Mongolia, Morocco, Myanmar, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Palestine, Portugal, Romania, Sardegna, Sicilia, Sinai, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Turkey, Turkey-in-Europe, Tuva, Ukraine, Uzbekistan, Vietnam, West Himalaya, West Siberia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | After 24, 48, and 72 h of treatment, the IC50levels were: 992 ± 2.3 μg/mL, 893 ± 5.4 μg/mL, and 785 ± 4.8 μg/mL against MDA-MB-468, respectively. 1288 ± 5.6 μg/mL, 926 ± 2.5 μg/mL, and 921 ± 3.5 μg/mL, against MCF-7, respectively. | |
| Potency | Hydroalcoholic extract of M. chamomilla prevents colonization and cellular migration of human breast cancer MDA-MB-468 and MCF-7 cell lines in a time- and dose-dependent manner.M. chamomilla has low cytotoxic effects on natural cells. | |
| Cell line/ mice model | MDA-MB-468, MCF-7 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | 28250660 34463438 32885425 27644672 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:154715-2 | |
| Safety | NA |