| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1656 |
| Phytochemical name or plant extracts | Matcha green tea (MGT) |
| PMID | 30153655 |
| Literature evidence | Our results indicate that MGT is indeed sufficient to inhibit the propagation of breast cancer stem cells (CSCs), with an IC-50 of ~0.2 mg/ml, in tissue culture. |
| IUPAC name | NA |
| Phytochemicals’ class or type of plant extracts | Green tea |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | NA |
| Gene or Protein evidence | NA |
| Target pathways | mTOR signalling |
| IC50 | NA |
| Potency | Our results are consistent with the idea that MGT may have significant therapeutic potential, by mediating the metabolic reprogramming of cancer cells. |
| Cell line/ mice model | MCF-7 |
| Additional information | Our results indicate that MGT strongly affected mTOR signalling, specifically down-regulating many components of the 40S ribosome. This raises the intriguing possibility that MGT can be used as inhibitor of mTOR, instead of chemical compounds, such as rapamycin. In addition, other key pathways were affected, including the anti-oxidant response, cell cycle regulation, as well as interleukin signalling. |
| PubChem ID | NA |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |