| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-791 | |
| Phytochemical name or plant extracts | Marmin | |
| PMID | 23434131 | |
| Literature evidence | Thus, these compounds may inhibit HIF-1 activation by suppressing mitochondria-mediated hypoxic signaling. | |
| IUPAC name | 7-[(E,6R)-6,7-dihydroxy-3,7-dimethyloct-2-enoxy]chromen-2-one | |
| Phytochemicals’ class or type of plant extracts | Geranyloxycoumarin | |
| Source of phytochemicals or plant Extracts | Aegle marmelos | |
| Geographical availability | Assam, Bangladesh, India, Nepal, Pakistan, West Himalaya | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | >30 µM against T47D (conditions - 1% O2, 16 h and 10 μM 1,10-phen, 16 h) | |
| Potency | NA | |
| Cell line/ mice model | T47D | |
| Additional information | While these findings suggest that geranyloxycoumarins potentially exert antitumor effects by inhibiting hypoxia-induced HIF-1 activation, these results also imply that these relatively common phytochemicals may have the potential to induce mitochondrial poison-associated toxicities, such as liver damage29 and neurodegeneration | |
| PubChem ID | 6450230 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:770819-1 | |
| Safety | NA |