| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-697 | |
| Phytochemical name or plant extracts | Maprang seed extract | |
| PMID | 32382295 | |
| Literature evidence | MPSE treatment decreased cell proliferation in MCF-7 cells, and MPSE was postulated to induce G2/M phase cell cycle arrest. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Bouea macrophylla | |
| Geographical availability | Andaman Is., Jawa, Malaya, Sumatera, Thailand | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | In addition, MPSE treatment can lead to increase in the Bax/Bcl-2 gene expression ratio, suggesting that MPSE-induced apoptosis is mitochondria-dependent pathway. | |
| Target pathways | Mitochondria-mediated apoptosis pathway. | |
| IC50 | At 72 h : 6.94 ± 1.57 μg/mL against MCF-7 18.92 ± 1.20 μg/mL against MDA-MB-231 | |
| Potency | Our results suggest that natural products obtained from maprang seeds have the potential to target the apoptosis pathway in breast cancer treatments. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | MPSE treatment decreased cell proliferation in MCF-7 cells, and MPSE was postulated to induce G2/M phase cell cycle arrest. MPSE was found to promote intracellular ROS production in MCF-7 treated cells and to also influence the depolarization of mitochondrial membrane potential. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:69262-1 | |
| Safety | NA |